T-cell exhaustion due to persistent antigen: quantity not quality?
- PMID: 22949327
- PMCID: PMC3684559
- DOI: 10.1002/eji.201242852
T-cell exhaustion due to persistent antigen: quantity not quality?
Abstract
T-cell exhaustion is characterized by failure to respond to a persistent antigen and is a hallmark of chronic infections and cancer. Here, we discuss several recent reports on T-cell exhaustion, including one in this issue of the European Journal of Immunology where Richter et al. [Eur. J. Immunol. 42:2290-2304] examine the importance of the amount of persistent antigen versus the cell type presenting it to induce CD8(+) T-cell exhaustion, and the consequences for host survival during chronic viral infection.
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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