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. 2012 Oct 9;126(15):1821-7.
doi: 10.1161/CIRCULATIONAHA.112.098061. Epub 2012 Sep 4.

Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men

Qibin Qi  1 , Yanping Li, Andrea K Chomistek, Jae H Kang, Gary C Curhan, Louis R Pasquale, Walter C Willett, Eric B Rimm, Frank B Hu, Lu Qi
Affiliations

Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men

Qibin Qi et al. Circulation. .

Abstract

Background: Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching.

Methods and results: We analyzed interactions between TV watching, leisure time physical activity, and genetic predisposition in relation to body mass index (BMI) in 7740 women and 4564 men from 2 prospective cohorts: The Nurses' Health Study and the Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years before assessment of BMI. A weighted genetic risk score was calculated on the basis of 32 established BMI-associated variants. In both women and men, the genetic associations with BMI strengthened with increased hours of TV watching. An increment of 10 points in the weighted genetic risk score was associated with 0.8 (SE, 0.4), 0.8 (SE, 0.2), 1.4 (SE, 0.2), 1.5 (SE, 0.2), and 3.4 (SE, 1.0) kg/m(2) higher BMI across the 5 categories of TV watching (0-1, 2-5, 6-20, 21-40, and >40 h/wk; P for interaction=0.001). In contrast, the genetic association with BMI weakened with increased levels of physical activity. An increment of 10 points in the weighted genetic risk score was associated with 1.5 (SE, 0.2), 1.3 (SE, 0.2), 1.2 (SE, 0.2), 1.2 (SE, 0.2), and 0.8 (SE, 0.2) kg/m(2) higher BMI across the quintiles of physical activity. The interactions of TV watching and physical activity with genetic predisposition in relation to BMI were independent of each other.

Conclusions: A sedentary lifestyle, indicated by prolonged TV watching, may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.

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Figures

Figure 1
Figure 1. Differences in effect of the weighted GRS on BMI associated with physical activity and TV watching
Data are based on the first 2 year of follow-up after the assessments of physical activity (1986-1988 in women and men) and TV watching (1992-1994 in women, 1988-1990 in men). Differences in genetic effect on BMI (beta [95% CI] for interaction) are reported for each additional 10 points of the weighted GRS associated with increased hours of total physical activity, vigorous activity, walking or TV watching, adjusted for age, genotype data source, disease status, smoking, alcohol intake, menopausal status (women only), total energy intake, vigorous activity (walking analysis only), walking (vigorous activity analysis only), and total physical activity (TV watching analysis only).
Figure 2
Figure 2. Difference in BMI per 10 points of the weighted GRS according to joint classification of physical activity and TV watching
Data are based on the first 2 years of follow-up after the both assessments of physical activity and TV watching in women (1992-1994) and men (1988-1990). Data are differences in BMI (kg/m2) per 10 points of the weighted GRS pooled from women and men, adjusted for age, genotype data source, disease status, smoking, alcohol intake, menopausal status (women only), and total energy intake.
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