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. 2012 Sep;4(5):309-10.
doi: 10.4168/aair.2012.4.5.309. Epub 2012 Mar 29.

A case of allopurinol-induced fixed drug eruption confirmed with a lymphocyte transformation test

Min-Hye Kim  1 , Eun-Jin Shim, Jae-Woo Jung, Seong-Wook Sohn, Hye-Ryun Kang
Affiliations

A case of allopurinol-induced fixed drug eruption confirmed with a lymphocyte transformation test

Min-Hye Kim et al. Allergy Asthma Immunol Res. 2012 Sep.

Abstract

Allopurinol is one of the causative drugs that induce fixed drug eruption (FDE). The lymphocyte transformation test (LTT) is a safe and reliable diagnostic procedure for drug allergy, but is reported to be rarely positive in patients with FDE. In the current case, we performed an LTT and successfully confirmed allopurinol as the offending drug. This case report suggests that an LTT should be an optional diagnostic tool for FDE or delayed reaction due to allopurinol.

Keywords: Allopurinol; fixed drug eruption; lymphocyte transformation test.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Figure
Figure
Result of lymphocyte transformation test with increasing dose of allopurinol.
See this image and copyright information in PMC

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