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Review
. 2012 Sep 1;4(9):a007021.
doi: 10.1101/cshperspect.a007021.

Treg cells, life history, and diversity

Christophe Benoist  1 , Diane Mathis
Affiliations
Review

Treg cells, life history, and diversity

Christophe Benoist et al. Cold Spring Harb Perspect Biol. .

Abstract

Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.

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References

    1. Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, et al. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12: 178–180 - PubMed
    1. Akimova T, Beier UH, Wang L, Levine MH, Hancock WW 2011. Helios expression is a marker of T cell activation and proliferation. PLoS ONE 6: e24226. - PMC - PubMed
    1. Apostolou I, von Boehmer H 2004. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 199: 1401–1408 - PMC - PubMed
    1. Apostolou I, Sarukhan A, Klein L, von Boehmer H 2002. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3: 756–763 - PubMed
    1. Aricha R, Feferman T, Fuchs S, Souroujon MC 2008. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. J Immunol 180: 2132–2139 - PubMed

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