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Review
. 2012 Sep 1;4(9):a011189.
doi: 10.1101/cshperspect.a011189.

PI3K-PKB/Akt pathway

Brian A Hemmings  1 , David F Restuccia
Affiliations
Review

PI3K-PKB/Akt pathway

Brian A Hemmings et al. Cold Spring Harb Perspect Biol. .

Erratum in

  • The PI3K-PKB/Akt pathway.
    Hemmings BA, Restuccia DF. Hemmings BA, et al. Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4):a026609. doi: 10.1101/cshperspect.a026609. Cold Spring Harb Perspect Biol. 2015. PMID: 25833846 Free PMC article. No abstract available.

Abstract

Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).

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Figures

Figure 1.
Figure 1.
PKB/Akt activation downstream of RTKs via the P13K pathway.
Figure 2.
Figure 2.
Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt.
See this image and copyright information in PMC

References

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