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Comment
. 2012 Aug;10(8):e1001385.
doi: 10.1371/journal.pbio.1001385. Epub 2012 Aug 28.

How a blood cell intracellular signal keeps blood flowing

Richard Robinson  1
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Comment

How a blood cell intracellular signal keeps blood flowing

Richard Robinson. PLoS Biol. 2012 Aug.
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

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The hormone erythropoietin (Epo) stimulates differentiation of bone-marrow erythroblasts into red cells by activating a binary intracellular Stat5 signal. In hypoxic stress, higher Epo increases red cell production by generating a graded Stat5 signal that reaches high intensities in early (large) erythroblasts.
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