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Case Reports
. 2012:2012:497604.
doi: 10.1155/2012/497604. Epub 2012 Jul 26.

Kikuchi-fujimoto disease: a case report and literature review

Vikrant Veer  1 , Albert Lim, Wolfgang Issing
Affiliations
Case Reports

Kikuchi-fujimoto disease: a case report and literature review

Vikrant Veer et al. Case Rep Otolaryngol. 2012.

Abstract

Case. 38-year-old lady was referred to the ENT clinic with history of right-sided facial pain, otalgia, and odynophagia. Clinical examination revealed enlarged right-sided lymph nodes in the neck. Further radiological scans showed a mass near the carotid and enlarged level V lymph nodes. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotising lymphadenitis. Literature Review. Kikuchi-Fujimoto disease (KFD) was described in 1972 as lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. KFD, frequently found in East Asian countries, is rare in the UK. No definite aetiology of KFD is known despite autoimmune and infection factors being suggested. The diagnostic hallmark is histological findings from lymph nodes. Malignancy should be excluded. This condition is mainly self-limiting; hence, management is limited to supportive care. Steroid therapy could be used in severe cases. KFD is relatively unknown in the UK and this case report aims to highlight its occurrence in our population.

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Figures

Figure 1
Figure 1
MRI scans of our patient showed multiple right-sided swollen lymph nodes. They were subsequently biopsied.
Figure 2
Figure 2
Histological staining for CD8+ lymphocytes infiltration of right-sided swollen lymph node biopsy.
See this image and copyright information in PMC

References

    1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Nippon Ketsueki Gakkai Zasshi. 1972;35:379–380.
    1. Fujimoto Y, Kojima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A New Clinicopathological Entity. 1972;20:920–927.
    1. Lin HC, Su CY, Huang CC, Hwang CF, Chien CY. Kikuchi’s disease: a review and analysis of 61 cases. Otolaryngology. 2003;128(5):650–653. - PubMed
    1. Heikens J, Tel W, van de Stadt J, de Koning J, Ten Napel CHH. Kikuchi’s lymphadenitis: report of a Yersinia enterocolitica-associated case and an overview of aetiology and clinical outcome. Netherlands Journal of Medicine. 1992;41(5-6):222–228. - PubMed
    1. Charalabopoulos K, Papalimneou V, Charalabopoulos A, Bai M, Agnantis N. Brucella melitensis infection stimulates an immune response leading to Kikuchi-Fujimoto disease. In Vivo. 2003;17(1):51–53. - PubMed

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