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Case Reports
. 1990 Jan;36(1):152-4.
doi: 10.1016/0090-8258(90)90127-7.

5-Fluorouracil neurotoxicity

D H Moore  1 , W C Fowler Jr, L S Crumpler
Affiliations
Case Reports

5-Fluorouracil neurotoxicity

D H Moore et al. Gynecol Oncol. 1990 Jan.

Abstract

Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.

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