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Review
. 2012 Nov;24(6):602-8.
doi: 10.1097/BOR.0b013e328358bd85.

Myositis autoantibodies

Livia Casciola-Rosen  1 , Andrew L Mammen
Affiliations
Review

Myositis autoantibodies

Livia Casciola-Rosen et al. Curr Opin Rheumatol. 2012 Nov.

Abstract

Purpose of review: To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.

Recent findings: Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.

Summary: As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.

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Conflict of interest statement

CONFLICT OF INTEREST

Drs. Casciola-Rosen and Mammen have a patent for an anti-HMGCR antibody test.

References

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    1. Casciola-Rosen L, Nagaraju K, Plotz P, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med. 2005 Feb 21;201(4):591–601. - PMC - PubMed

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