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. 2012 Sep;18(6):290-3.
doi: 10.1097/RHU.0b013e3182675e4f.

Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA

Amanda Kyle Scofield  1 , Lida Radfar, John A Ice, Evan Vista, Juan-Manuel Anaya, Glen Houston, David Lewis, Donald U Stone, James Chodosh, Kimberly Hefner, Christopher J Lessard, Kathy L Moser, Robert Hal Scofield
Affiliations

Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA

Amanda Kyle Scofield et al. J Clin Rheumatol. 2012 Sep.

Abstract

Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.

Methods: Eight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay.

Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome.

Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

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