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. 2012 Oct 25;120(17):3488-90.
doi: 10.1182/blood-2012-07-445593. Epub 2012 Sep 6.

HTLV-1-infected T cells contain a single integrated provirus in natural infection

Lucy B Cook  1 , Aileen G Rowan, Anat Melamed, Graham P Taylor, Charles R M Bangham
Affiliations

HTLV-1-infected T cells contain a single integrated provirus in natural infection

Lucy B Cook et al. Blood. .

Abstract

Human T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput sequencing study revealed a large number (often > 10(4)) of distinct proviral integration sites of HTLV-1 in each host that is greatly in excess of previous estimates. Here we use the highly sensitive, quantitative high-throughput sequencing protocol to show that circulating HTLV-1(+) clones in natural infection each contain a single integrated proviral copy. We conclude that a typical host possesses a large number of distinct HTLV-1-infected T-cell clones.

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