Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Oct;25 Suppl 4(0 4):22-5.
doi: 10.3109/14767058.2012.715005.

Haematological abnormalities in neonatal necrotizing enterocolitis

Rhonnie Song  1 , Girish C Subbarao, Akhil Maheshwari
Affiliations
Review

Haematological abnormalities in neonatal necrotizing enterocolitis

Rhonnie Song et al. J Matern Fetal Neonatal Med. 2012 Oct.

Abstract

Objective: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological abnormalities associated with NEC.

Methods: A literature search was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies.

Results: Thrombocytopenia, disseminated intravascular coagulation, increased or decreased neutrophil counts, and hemolytic anemia are frequent events in NEC.

Conclusions: NEC is associated with several hematological abnormalities, which may play a direct or indirect role in the pathogenesis of gut mucosal injury, and may also carry important prognostic information.

PubMed Disclaimer

References

    1. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011 Jan 20;364(3):255–64. - PMC - PubMed
    1. Maheshwari A, Corbin LL, Schelonka RL. Neonatal Necrotizing Enterocolitis. Res Rep Neonatol. 2011;1:39–53.
    1. Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, et al. TGF-beta(2) Suppresses Macrophage Cytokine Production and Mucosal Inflammatory Responses in the Developing Intestine. Gastroenterology. 2011 Jan;140(1):242–53. - PMC - PubMed
    1. Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am. 1986 Feb;33(1):179–201. - PMC - PubMed
    1. Hutter JJ, Jr., Hathaway WE, Wayne ER. Hematologic abnormalities in severe neonatal necrotizing enterocolitis. J Pediatr. 1976 Jun;88(6):1026–31. - PubMed

Publication types

MeSH terms