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Comment
. 2012 Sep 6;75(5):742-4.
doi: 10.1016/j.neuron.2012.08.023.

The clathrin adaptor complex responsible for somatodendritic protein sorting

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Comment

The clathrin adaptor complex responsible for somatodendritic protein sorting

Marvin Bentley et al. Neuron. .

Abstract

Neuronal proteins contain "address labels" that govern their localization. In this issue of Neuron, Farías et al. (2012) identify the machinery that recognizes one class of dendritic localization signals and establish its role in the polarization of dendritic proteins, including several postsynaptic receptors.

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References

    1. Burack MA, Silverman MA, Banker G. The role of selective transport in neuronal protein sorting. Neuron. 2000;26:465–472. - PubMed
    1. Dotti CG, Simons K. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture. Cell. 1990;62:63–72. - PubMed
    1. Farías GG, Cuitino L, Guo X, Ren X, Jarnik M, Mattera R, Bonifacino JS. Signal-mediated, AP-1/Clathrin-dependent Sorting of Transmembrane Receptors to the Somatodendritic Domain of Hippocampal Neurons. Neuron 2012 - PMC - PubMed
    1. Fölsch H, Ohno H, Bonifacino JS, Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell. 1999;99:189–198. - PubMed
    1. Gravotta D, Carvajal-Gonzalez JM, Mattera R, Deborde S, Banfelder JR, Bonifacino JS, Rodriguez-Boulan E. The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell. 2012;22:811–823. - PMC - PubMed

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