Case Reports
Altered biodistribution of gallium-67 in a patient with aluminum toxicity treated with desferoxamine
Affiliations
- PMID: 2295931
Item in Clipboard
Case Reports
Altered biodistribution of gallium-67 in a patient with aluminum toxicity treated with desferoxamine
J Nucl Med.
1990 Jan.
Free article
Abstract
Markedly altered biodistribution of [67Ga]citrate was observed in a 66-yr-old hemodialysis patient imaged at 48 hr postinjection. A review of the patient's hospital records revealed toxic serum levels of aluminum, treated with the chelating agent desferoxamine. Based on what is known about the biologic interactions between gallium, aluminum, transferrin, and desferoxamine, we believe that both toxic serum aluminum levels and desferoxamine therapy may cause altered biodistribution on [67Ga]citrate scintigraphy.
Similar articles
-
Encephalopathy in chronic renal failure responsive to deferoxamine therapy. Another manifestation of aluminum neurotoxicity.Arch Intern Med. 1986 Oct;146(10):2063-4. Arch Intern Med. 1986. PMID: 3767553
-
Uptake of aluminum and gallium into tissues of the rat: influence of antibody against the transferrin receptor.Biol Trace Elem Res. 1998 Apr-May;62(1-2):51-64. doi: 10.1007/BF02820021. Biol Trace Elem Res. 1998. PMID: 9630424
-
Gallium-67 citrate in liquid gastric emptying scintigraphy.J Nucl Med. 1993 Sep;34(9):1619-20. J Nucl Med. 1993. PMID: 8355086 No abstract available.
-
Risk factors in aluminum toxicity in children with chronic renal failure.Nephron. 1986;42(3):189-95. doi: 10.1159/000183665. Nephron. 1986. PMID: 3511396 Review. No abstract available.
-
The chemistry of desferrioxamine chelation for aluminum overload in renal dialysis patients.Ther Drug Monit. 1993 Dec;15(6):598-601. doi: 10.1097/00007691-199312000-00026. Ther Drug Monit. 1993. PMID: 8122301 Review.
Cited by
-
In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites.Biomater Res. 2021 Mar 31;25(1):7. doi: 10.1186/s40824-021-00210-0. Biomater Res. 2021. PMID: 33789768 Free PMC article.
-
Adverse reactions and drug interactions with radiopharmaceuticals.Drug Saf. 1993 Apr;8(4):280-94. doi: 10.2165/00002018-199308040-00003. Drug Saf. 1993. PMID: 8481215 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
