Review
doi: 10.1016/j.molimm.2012.08.017.
Epub 2012 Sep 7.
Ficolins in complement activation
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- PMID: 22959617
- DOI: 10.1016/j.molimm.2012.08.017
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Review
Ficolins in complement activation
Mol Immunol.
2013 Aug.
Abstract
Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc). Ficolins in serum are complexed with MBL-associated serine proteases (MASPs) and their truncated proteins. These lectins play an important role in innate immunity. Binding of the ficolin-MASP complex to carbohydrates present on the surface of microbes initiates complement activation via the lectin pathway.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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