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Review
. 2012:59:75-8.
doi: 10.1227/NEU.0b013e31826b2e8b.

Adjuncts for maximizing resection: 5-aminolevuinic acid

David W Roberts, Pablo A Valdés, Brent T Harris, Alexander Hartov, Xiaoyao Fan, Songbai Ji, Brian W Pogue, Frederic Leblond, Tor D Tosteson, Brian C Wilson, Keith D Paulsen
Review

Adjuncts for maximizing resection: 5-aminolevuinic acid

David W Roberts et al. Clin Neurosurg. 2012.
No abstract available

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Figures

FIGURE 1
FIGURE 1
A, during resection along the lateral aspect of this glioblastoma multiforme, the overlaid contour representing the preoperatively segmented contrast-enhancement on MRI provides a general guide to the proposed extent of resection. B, under violet-blue light conditions, fluorescence in the tissue corresponding to that MRI contrast enhancement facilitates resection of that tissue.
FIGURE 2
FIGURE 2
A, near the end of resection of this glioblastoma multiforme, residual tumor is not evident by either image guidance or white light appearance of the tissue. B, under blue light conditions, remaining tumor, corresponding to a portion of the gadolinium-enhancing tumor on MRI, is readily appreciated.
FIGURE 3
FIGURE 3
A, during resection along the lateral aspect of this mixed oligoastrocytoma, the overlaid contour indicates the planned margin of resection on preoperative MRI. B, under violet-blue light conditions, no visible fluorescence is evident. C, under violet-blue light conditions, the handheld probe can be seen at the same presumed tumor margin. D, quantitative protoporphyrin IX (PpIX) data obtained from the handheld probe shows the characteristic spectral signal of PpIX with a major peak at 635 nm and a concentration of PpIX of 0.21 μg/mL, a value consistent with tumor tissue.
See this image and copyright information in PMC

References

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    1. Hefti M, von Campe G, Moschopulos M, Siegner A, Looser H, Landolt H. 5-Aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institution. Swiss Med Wkly. 2008;138(11-12):180–185. - PubMed

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