RING-between-RINGs--keeping the safety on loaded guns
- PMID: 22960632
- PMCID: PMC3463855
- DOI: 10.1038/emboj.2012.260
RING-between-RINGs--keeping the safety on loaded guns
Abstract
EMBO J (2012) 31 19, 3833–3844 doi:; DOI: 10.1038/emboj.2012.217; published online September 07 2012
EMBO Rep (2012) 13 9, 840–846 doi:; DOI: 10.1038/embor.2012.105; published online September 07 2012
The ‘RING-between-RING’-type E3 ubiquitin ligase HOIP acts via a novel RING/HECT-hybrid ubiquitin transfer mechanism and catalyses the formation of linear ubiquitin chains by non-covalently binding the acceptor ubiquitin. But in the absence of a binding partner, HOIP is auto-inhibited. This explains why assembly of either HOIP/HOIL-1L or HOIP/SHARPIN is required to catalyse linear chain formation.
Conflict of interest statement
The authors declare that they have no conflict of interest.
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Comment on
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The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.EMBO J. 2012 Oct 3;31(19):3833-44. doi: 10.1038/emboj.2012.217. Epub 2012 Aug 3. EMBO J. 2012. PMID: 22863777 Free PMC article.
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