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Clinical Trial
. 2012 Nov;53(11):1730-5.
doi: 10.2967/jnumed.112.104893. Epub 2012 Sep 7.

Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients

Sheng-Chieh Chan  1 , Hung-Ming Wang, Shu-Hang Ng, Cheng-Lung Hsu, Yu-Jr Lin, Chien-Yu Lin, Chun-Ta Liao, Tzu-Chen Yen
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Free article
Clinical Trial

Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients

Sheng-Chieh Chan et al. J Nucl Med. 2012 Nov.
Free article

Abstract

This study compared the diagnostic accuracy of (18)F-FDG PET/CT with that of (18)F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients.

Methods: The study participants underwent (18)F-FDG PET/CT and (18)F-fluoride PET/CT within 2 wk of each another.

Results: A total of 98 bony metastases were found in 18 of our 80 patients. (18)F-fluoride PET/CT and (18)F-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P = 0.126) and areas under the curve (0.7561 vs. 0.7959, P = 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P < 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients.

Conclusion: (18)F-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to (18)F-FDG PET/CT. Their combined use may not be justifiable.

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