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Review
. 2012 Nov;13(6):743-6.
doi: 10.1093/bib/bbs020. Epub 2012 Sep 8.

Metagenomic analysis: the challenge of the data bonanza

Chris I Hunter  1 , Alex Mitchell, Philip Jones, Craig McAnulla, Sebastien Pesseat, Maxim Scheremetjew, Sarah Hunter
Affiliations
Review

Metagenomic analysis: the challenge of the data bonanza

Chris I Hunter et al. Brief Bioinform. 2012 Nov.

Abstract

Several thousand metagenomes have already been sequenced, and this number is set to grow rapidly in the forthcoming years as the uptake of high-throughput sequencing technologies continues. Hand-in-hand with this data bonanza comes the computationally overwhelming task of analysis. Herein, we describe some of the bioinformatic approaches currently used by metagenomics researchers to analyze their data, the issues they face and the steps that could be taken to help overcome these challenges.

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References

    1. Wooley JC, Godzik A, Friedberg I. A primer on metagenomics. PLoS Comput Biol. 2010;6(2):e1000667. - PMC - PubMed
    1. Gilbert J, Dupont C. Microbial metagenomics: beyond the genome. Annu Rev Marine Sci. 2011;3:347–71. - PubMed
    1. Hildebrandt A, Lacorte S, Barceló D. Sampling of water, soil and sediment to trace organic pollutants at a river-basin scale. Anal Bioanal Chem. 2006;386(4):1075–88. - PubMed
    1. Zhou X, Ren L, Li Y, et al. The next-generation sequencing technology: a technology review and future perspective. Sci China Life Sci. 2010;53(1):44–57. - PubMed
    1. Meyer F, Paarmann D, D’Souza M, et al. The metagenomics RAST server—a public resource for the automatic phylogenetic and functional analysis of metagenomes. BMC Bioinformatics. 2008;9:386. - PMC - PubMed