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. 2012:6:65-70.
doi: 10.2174/1874205X01206010065. Epub 2012 Aug 17.

Migraine and genetic polymorphisms: an overview

Vincenzo Pizza  1 , Anella Agresta, Antonio Agresta, Eros Lamaida, Norman Lamaida, Francesco Infante, Anna Capasso
Affiliations

Migraine and genetic polymorphisms: an overview

Vincenzo Pizza et al. Open Neurol J. 2012.

Abstract

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

Keywords: Genetic Polymorphisms; Migraine; Thrombosis; Vascular Disease..

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Figures

Fig. (1)
Fig. (1)
Integrated pathogenetic model of migraine.
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