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. 2012 Sep 21;14(18):4770-3.
doi: 10.1021/ol302051x. Epub 2012 Sep 10.

Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song  1 , Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang, Robert J Capon
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Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song et al. Org Lett. .

Abstract

An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

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