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Review
. 2012 Nov;217(11):1026-33.
doi: 10.1016/j.imbio.2012.07.024. Epub 2012 Aug 7.

The complement system in ischemia-reperfusion injuries

William B Gorsuch  1 , Elvina Chrysanthou, Wilhelm J Schwaeble, Gregory L Stahl
Affiliations
Review

The complement system in ischemia-reperfusion injuries

William B Gorsuch et al. Immunobiology. 2012 Nov.

Abstract

Tissue injury and inflammation following ischemia and reperfusion of various organs have been recognized for many years. Many reviews have been written over the last several decades outlining the role of complement in ischemia/reperfusion injury. This short review provides a current state of the art knowledge on the complement pathways activated, complement components involved and a review of the clinical biologics/inhibitors used in the clinical setting of ischemia/reperfusion. This is not a complete review of the complement system in ischemia and reperfusion injury but will give the reader an updated view point of the field, potential clinical use of complement inhibitors, and the future studies needed to advance the field.

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Figures

Figure 1
Figure 1
Brief graphical representation of the complement system.
See this image and copyright information in PMC

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