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. 2012 Oct 15;51(42):10518-22.
doi: 10.1002/anie.201205247. Epub 2012 Sep 10.

Single-molecule visualization of the hybridization and dissociation of photoresponsive oligonucleotides and their reversible switching behavior in a DNA nanostructure

Masayuki Endo  1 , Yangyang Yang, Yuki Suzuki, Kumi Hidaka, Hiroshi Sugiyama
Affiliations

Single-molecule visualization of the hybridization and dissociation of photoresponsive oligonucleotides and their reversible switching behavior in a DNA nanostructure

Masayuki Endo et al. Angew Chem Int Ed Engl. .

Abstract

A framed photo of DNA: A pair of photoresponsive oligonucleotides containing azobenzene moieties was introduced into double-stranded DNA within the cavity of a DNA nanostructure (see scheme). The two dsDNAs, in contact at the center, were dissociated using UV irradiation and hybridized with visible light; this was directly observed using high-speed atomic force microscopy.

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