Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;100(1):138-40.
doi: 10.1007/BF02245806.

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

P Whitton  1 , G Curzon
Affiliations

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

P Whitton et al. Psychopharmacology (Berl). 1990.

Abstract

1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT1C receptors with an ED50 of approximately 500 micrograms/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 micrograms of the drug ICV or infusing 0.5 microgram into the hippocampus. Both responses were dose dependent. Infusion of 1 microgram mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Psychiatry. 1983 Nov;44(11 Pt 2):5-11 - PubMed
    1. J Clin Endocrinol Metab. 1985 Dec;61(6):1179-84 - PubMed
    1. Br J Pharmacol. 1988 May;94(1):137-47 - PubMed
    1. Brain Res. 1986 Apr 16;371(1):123-32 - PubMed
    1. Psychopharmacology (Berl). 1987;92(1):14-24 - PubMed

Publication types