Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;100(1):98-101.
doi: 10.1007/BF02245797.

Pirenperone does not attenuate morphine analgesia in spinal rats

D Paul  1 , J P Pinel
Affiliations

Pirenperone does not attenuate morphine analgesia in spinal rats

D Paul et al. Psychopharmacology (Berl). 1990.

Abstract

The selective serotonin type-2 (S2) receptor blocker pirenperone (0.24 mg/kg, SC) attenuates morphine-produced tail-flick antinociception in intact rats, but not in rats with transected spinal cords. These results suggest that S2 receptor blockade does not affect intraspinal opioid antinociception. Together with evidence that there are virtually no S2 receptors in the dorsal spinal cord, supraspinal S2 receptors are implicated in the mediation of morphine-produced antinociception.

PubMed Disclaimer

References

    1. Brain Res. 1976 Mar 12;104(2):367-72 - PubMed
    1. Brain Res. 1983 Aug 29;273(2):245-52 - PubMed
    1. Brain Res. 1983 Dec 12;288(1-2):338-43 - PubMed
    1. Pharmacol Biochem Behav. 1988 Nov;31(3):641-7 - PubMed
    1. Eur J Pharmacol. 1982 Jun 16;81(1):43-8 - PubMed

Publication types

LinkOut - more resources