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. 2010 May;1(3):453-456.
doi: 10.3892/ol_00000080. Epub 2010 May 1.

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Shiqian Zhang  1 , Hao Yu, Linlin Zhang
Affiliations

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Shiqian Zhang et al. Oncol Lett. 2010 May.

Abstract

The present study was designed to investigate the role of vascular endothelial growth factor receptor (VEGFR)-3/Flt-4 in the early stages of cervical cancer. VEGFR-3/Flt-4 expression, vascular endothelial growth factor (VEGF)-C and VEGF-D in the early stages (Ia-IIa) of cervical cancer in 41 patients was examined by immunohistochemical analysis. Additionally, the VEGFR-3/Flt-4-marked vascular density (MVD) was examined and the relationship of these factors with clinicopathological factors was analyzed. VEGFR-3/Flt-4 was found to be expressed in lymphatic endothelial cells and, to a certain extent, in vascular endothelial cells. The VEGFR-3/Flt-4-positive vessels were largely distributed in the stroma surrounding the tumor tissues, and these vessels were morphologically divided into blood and lymphatic vessels, respectively. Cancer cells were found to express VEGF-C, VEGF-D and VEGFR-3/Flt-4, and their positive expression rate was 48.7% (20/41), 58.5% (24/41) and 63.4% (26/41), respectively. VEGFR-3/Flt-4 expression in the cancer cells of the cervical cancer patients in our study was found to be correlated to the clinical stage, lymph node metastasis, lymphatic invasion and expression of VEGF-C and VEGF-D. However, this expression was unrelated to menstrual status, histological grade and histological classification. MVD was correlated to the clinical stage and expression of VEGF-C and VEGF-D, but was unrelated to menstrual status, histological grade, histological classification, lymph node metastasis and lymphatic invasion. In conclusion, VEGFR-3/Flt-4 plays an important role in the early stages of cervical cancer.

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Figures

Figure 1
Figure 1
VEGFR-3/Flt-4 expression in early-stage cervical cancer tissues. (A) VEGFR-3/Flt-4 is expressed in inflammatory cells. (B) VEGFR-3/Flt-4-positive vessels were distributed in the stroma. (C) Cancer cells were found in VEGFR-positive vessels. (D-F) Cancer cells were found to express VEGFR-C, VEGFR-D and VEGFR-3/Flt-4.
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References

    1. Su JL, Yen CJ, Chen PS, et al. The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 2007;96:541–545. - PMC - PubMed
    1. Jüttner S, Wissmann C, Jons T, et al. Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma. J Clin Oncol. 2006;24:228–240. - PubMed
    1. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis – correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1–8. - PubMed
    1. Rouzaut A, Irigoyen M, Montuenga LM. Lymphangiogenesis and lung cancer. J Thorac Oncol. 2007;2:384–386. - PubMed
    1. Yasuoka H, Nakamura Y, Zuo H, et al. VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. Mod Pathol. 2005;18:1127–1133. - PubMed

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