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. 2010 Jul;1(4):641-647.
doi: 10.3892/ol_00000113. Epub 2010 Jul 1.

Predictive value of Smac, VEGF and Ki-67 in rectal cancer treated with neoadjuvant therapy

Hongjiang Yan  1 , Renben Wang, Jinming Yu, Shumei Jiang, Kunli Zhu, Dianbin Mu, Zhongfa Xu
Affiliations

Predictive value of Smac, VEGF and Ki-67 in rectal cancer treated with neoadjuvant therapy

Hongjiang Yan et al. Oncol Lett. 2010 Jul.

Abstract

The present study aimed to identify whether second mitochondria-derived activator of caspase (Smac), vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (Ki-67) expression in pre-treatment tumor biopsies are useful predictive markers of tumor response in patients with rectal cancer undergoing pre-operative chemoradiotherapy (CRT). Paraffin-embedded tissues obtained before and after therapy were evaluated by immunohistochemical staining for Smac, VEGF and Ki-67. The study evaluated the correlation of Smac, VEGF and Ki-67 immunoreactivity in tumor biopsies before treatment of tumor response to pre-operative CRT. Regarding Smac, patients with a favorable response to neoadjuvant CRT had higher pre-therapy levels (p=0.011). The level of Smac expression decreased after neoadjuvant therapy (p=0.044). However, VEGF expression was found to be negatively and significantly correlated with a favorable tumor response to neoadjuvant CRT (p=0.010). A transient increase in VEGF expression was detected in the resected specimens following neoadjuvant therapy (p=0.030). In addition, tumors with a low Ki-67 labeling index (Ki-67-LI) expression were found to be more sensitive to neoadjuvant therapy than those with a high expression of Ki-67-LI (p=0.034). In contrast to VEGF, the Ki-67 expression level decreased after neoadjuvant therapy. Smac, VEGF and Ki-67 expression levels, assessed immunohistochemically from pre-treatment tumor biopsies, may be useful predictive markers of rectal tumor response to pre-operative CRT.

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Figures

Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
Figure 1
Figure 1
Smac, VEGF and Ki-67 expression. (A) Smac expression in a pre-treatment biopsy, 80%; (B) Smac expression in a surgical specimen, 15%; (C) VEGF expression in a pre-treatment biopsy, +; (D) VEGF expression in a surgical specimen, +++; (E) Ki-67 expression in a pre-treatment biopsy, 75%; (F) Ki-67 expression in a surgical specimen, 5%.
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