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. 2010 Sep;1(5):805-807.
doi: 10.3892/ol_00000141. Epub 2010 Sep 1.

Pseudoangiomatous stromal hyperplasia: An observation on its microscopic involvement in breast carcinoma and the presence of lymph node metastases

John D Coyne  1
Affiliations

Pseudoangiomatous stromal hyperplasia: An observation on its microscopic involvement in breast carcinoma and the presence of lymph node metastases

John D Coyne. Oncol Lett. 2010 Sep.

Abstract

The spaces of pseudoangiomatous stromal hyperplasia (PASH) are postulated to be important in the intramammary spread of breast carcinoma. The present study aimed to note the prevalence of inconspicuous, microscopic foci of PASH (identified as CD34+ve, CD31-ve and D2-40-ve spaces containing tumour emboli) involved in breast carcinoma and to establish the significance of its relationship to lymph node metastases. A total of 80 cases of breast carcinoma were examined for microscopic foci of PASH permeated by carcinoma and, of the four cases found to demonstrate such involvement, three had lymph node metastases.

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Figures

Figure 1
Figure 1
A barely conspicuous microscopic focus of pseudoangiomatous stromal hyperplasia involved by invasive carcinoma (H&E).
Figure 2
Figure 2
The same focus of invasive carcinoma within the microscopic spaces of pseudoangiomatous stromal hyperplasia highlighted by CD34 immunohistochemistry.
See this image and copyright information in PMC

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