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. 2012:2012:794043.
doi: 10.1155/2012/794043. Epub 2012 Aug 27.

Changes in heart rate variability of depressed patients after electroconvulsive therapy

Erica B Royster  1 , Lisa M Trimble, George Cotsonis, Brian Schmotzer, Amita Manatunga, Natasha N Rushing, Giuseppe Pagnoni, S Freda Auyeung, Angelo R Brown, Joel Schoenbeck, Smitha Murthy, William M McDonald, Dominique L Musselman
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Changes in heart rate variability of depressed patients after electroconvulsive therapy

Erica B Royster et al. Cardiovasc Psychiatry Neurol. 2012.

Abstract

Objective. As few, small studies have examined the impact of electroconvulsive therapy (ECT) upon the heart rate variability of patients with major depressive disorder (MDD), we sought to confirm whether ECT-associated improvement in depressive symptoms would be associated with increases in HRV linear and nonlinear parameters. Methods. After providing consent, depressed study participants (n = 21) completed the Beck Depression Index (BDI), and 15-minute Holter monitor recordings, prior to their 1st and 6th ECT treatments. Holter recordings were analyzed for certain HRV indices: root mean square of successive differences (RMSSD), low-frequency component (LF)/high-frequency component (HF) and short-(SD1) versus long-term (SD2) HRV ratios. Results. There were no significant differences in the HRV indices of RMSDD, LF/HF, and SD1/SD2 between the patients who responded, and those who did not, to ECT. Conclusion. In the short term, there appear to be no significant improvement in HRV in ECT-treated patients whose depressive symptoms respond versus those who do not. Future studies will reveal whether diminished depressive symptoms with ECT are reliably associated with improved sympathetic/parasympathetic balance over the long-term, and whether acute changes in sympathetic/parasympathetic balance predict improved mental- and cardiac-related outcomes.

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Figures

Figure 1
Figure 1
Heart rate in responders and nonresponders before ECT-1 and before ECT-6.
Figure 2
Figure 2
RMSSD in responders and nonresponders before ECT-1 and before ECT-6.
Figure 3
Figure 3
LF/HF ratio in responders and nonresponders before ECT-1 and before ECT-6.
Figure 4
Figure 4
SD1/SD2 in responders and nonresponders before ECT-1 and before ECT-6.
See this image and copyright information in PMC

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References

    1. Campbell RWF. Can analysis of heart rate variability predict arrhythmias and antiarrhythmic effects? In: Oto AM, editor. Practice and Progress in Cardiac Pacing and Electrophysiology. Dordrecht, Netherlands: Kluwer Academic Publishers; 1996. pp. 63–69.
    1. Task Force of the Europen Society of Cardiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. European Heart Journal. 1996;17:354–381. - PubMed
    1. Rechlin T, Weis M, Claus D. Heart rate variability in depressed patients and differential effects of paroxetine and amitriptyline on cardiovascular autonomic functions. Pharmacopsychiatry. 1994;27(3):124–128. - PubMed
    1. Rechlin T. The effect of amitriptyline, doxepin, fluvoxamine, and paroxetine treatment on heart rate variability. Journal of Clinical Psychopharmacology. 1994;14(6):392–395. - PubMed
    1. Carney RM, Saunders RD, Freedland KE, Stein P, Rich MW, Jaffe AS. Association of depression with reduced heart rate variability in coronary artery disease. American Journal of Cardiology. 1995;76(8):562–564. - PubMed