Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life
- PMID: 22967456
- PMCID: PMC3463445
- DOI: 10.1186/1743-7075-9-80
Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life
Abstract
Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal life, protein restriction during lactation did not appear to cause either obesity or the hallmarks of metabolic syndrome, such as hyperinsulinemia, when individuals reached adulthood. However, protein restriction provokes body underweight and hypoinsulinemia. This review is focused on the regulation of insulin secretion and the influence of the autonomic nervous system (ANS) in adult rats that were protein-malnourished during lactation. The data available on the topic suggest that the perinatal phase of lactation, when insulted by protein deficit, imprints the adult metabolism and thereby alters the glycemic control. Although hypoinsulinemia programs adult rats to maintain normoglycemia, pancreatic β-cells are less sensitive to secretion stimuli, such as glucose and cholinergic agents. These pancreatic dysfunctions may be attributed to an imbalance of ANS activity recorded in adult rats that experienced maternal protein restriction.
Figures
Similar articles
-
Protein-restriction diet during the suckling phase programs rat metabolism against obesity and insulin resistance exacerbation induced by a high-fat diet in adulthood.J Nutr Biochem. 2018 Jul;57:153-161. doi: 10.1016/j.jnutbio.2018.03.017. Epub 2018 Apr 3. J Nutr Biochem. 2018. PMID: 29730509
-
Protein restriction during lactation alters the autonomic nervous system control on glucose-induced insulin secretion in adult rats.Nutr Neurosci. 2007 Feb-Apr;10(1-2):79-87. doi: 10.1080/10284150701308693. Nutr Neurosci. 2007. PMID: 17539486
-
Malnutrition during late pregnancy exacerbates high-fat-diet-induced metabolic dysfunction associated with lower sympathetic nerve tonus in adult rat offspring.Nutr Neurosci. 2020 Jun;23(6):432-443. doi: 10.1080/1028415X.2018.1516845. Epub 2018 Sep 6. Nutr Neurosci. 2020. PMID: 30187832
-
Fetal growth restriction and consequences for the offspring in animal models.J Soc Gynecol Investig. 2003 Oct;10(7):392-9. doi: 10.1016/s1071-5576(03)00134-5. J Soc Gynecol Investig. 2003. PMID: 14519479 Review.
-
Programming of obesity and cardiovascular disease.Int J Obes Relat Metab Disord. 2004 Nov;28 Suppl 3:S46-53. doi: 10.1038/sj.ijo.0802800. Int J Obes Relat Metab Disord. 2004. PMID: 15543219 Review.
Cited by
-
Maternal low-protein diet during lactation combined with early overfeeding impair male offspring's long-term glucose homeostasis.Endocrine. 2019 Jan;63(1):62-69. doi: 10.1007/s12020-018-1719-9. Epub 2018 Aug 20. Endocrine. 2019. PMID: 30128960
-
Protein-energy malnutrition at mid-adulthood does not imprint long-term metabolic consequences in male rats.Eur J Nutr. 2016 Jun;55(4):1423-33. doi: 10.1007/s00394-015-0960-8. Epub 2015 Jul 2. Eur J Nutr. 2016. PMID: 26133298
-
Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity.J Physiol. 2019 Apr;597(7):1855-1872. doi: 10.1113/JP277637. Epub 2019 Mar 3. J Physiol. 2019. PMID: 30730556 Free PMC article.
References
-
- de Oliveira JC, Scomparin DX, Andreazzi AE, Branco RC, Martins AG, Gravena C, Grassiolli S, Rinaldi W, Barbosa FB, Mathias PC. Metabolic imprinting by maternal protein malnourishment impairs vagal activity in adult rats. J Neuroendocrinol. 2011;23:148–157. doi: 10.1111/j.1365-2826.2010.02095.x. - DOI - PubMed
LinkOut - more resources
Full Text Sources