RADAR reference adult, pediatric, and pregnant female phantom series for internal and external dosimetry
- PMID: 22967805
- PMCID: PMC4652945
- DOI: 10.2967/jnumed.112.106138
RADAR reference adult, pediatric, and pregnant female phantom series for internal and external dosimetry
Abstract
A new generation of reference computational phantoms, based on image-based models tied to the reference masses defined by the International Commission on Radiological Protection (ICRP) for dose calculations, is presented.
Methods: Anatomic models based on nonuniform rational b-spline modeling techniques were used to define reference male and female adults, 15-y-olds, 10-y-olds, 5-y-olds, 1-y-olds, newborns, and pregnant women at 3 stages of gestation, using the defined reference organ masses in ICRP publication 89. Absorbed fractions and specific absorbed fractions for internal emitters were derived using standard Monte Carlo radiation transport simulation codes.
Results: Differences were notable between many pairs of organs in specific absorbed fractions because of the improved realism of the models, with adjacent organs usually closer and sometimes touching. Final estimates of absorbed dose for radiopharmaceuticals, for example, were only slightly different overall, as many of the differences were small and most pronounced at low radiation energies. Some new important organs were defined (salivary glands, prostate, eyes, and esophagus), and the identity of a few gastrointestinal tract organs changed.
Conclusion: A new generation of reference models for standardized internal and external dose calculations has been defined. The models will be implemented in standardized software for internal dose calculations and be used to produce new standardized dose estimates for radiopharmaceuticals and other applications.
Conflict of interest statement
No other potential conflict of interest relevant to this article was reported.
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References
-
- Cristy M, Eckerman K. Specific Absorbed Fractions of Energy at Various Ages from Internal Photon Sources. Oak Ridge, TN: Oak Ridge National Laboratory; 1987. pp. 1–110. ORNL/TM-8381 V1-V7.
-
- Stabin M, Watson E, Cristy M, et al. Mathematical Models and Specific Absorbed Fractions of Photon Energy in the Nonpregnant Adult Female and at the End of Each Trimester of Pregnancy. Oak Ridge, TN: Oak Ridge National Laboratory; 1995. pp. 1–140. ORNL/TM-12907.
-
- Stabin M. MIRDOSE: the personal computer software for use in internal dose assessment in nuclear medicine. J Nucl Med. 1996;37:538–546. - PubMed
-
- Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023–1027. - PubMed
-
- Xu XG, Eckerman KF. Handbook of Anatomical Models for Radiation Dosimetry. Boca Raton, FL: Taylor and Francis; 2009. pp. 1–721.
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