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. 2012 Oct 29;51(44):11039-43.
doi: 10.1002/anie.201203780. Epub 2012 Sep 11.

Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim  1 , Taeho Kim, In-Young Choi, Min Soh, Dohoung Kim, Young-Ju Kim, Hyunduk Jang, Hye-Sung Yang, Jun Yup Kim, Hong-Kyun Park, Seung Pyo Park, Sangseung Park, Taekyung Yu, Byung-Woo Yoon, Seung-Hoon Lee, Taeghwan Hyeon
Affiliations

Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim et al. Angew Chem Int Ed Engl. .

Abstract

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

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