Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012:5:715-8.
doi: 10.2147/IJGM.S33549. Epub 2012 Aug 23.

Epstein-Barr virus-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement

Makoto Saito  1 , Masanobu Morioka, Ko Izumiyama, Akio Mori, Tatsuro Irie, Masanori Tanaka, Yoshihiro Matsuno
Affiliations
Case Reports

Epstein-Barr virus-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement

Makoto Saito et al. Int J Gen Med. 2012.

Abstract

We report a case of Epstein-Barr virus (EBV)-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement. A 34-year-old healthy Japanese male developed intussusception due to an ileal plasmacytoma. The lesion was positive for EBV-encoded small nuclear RNA in in situ hybridization, with the surrounding lymph nodes showing the expression of CD20. Tumor cells in the ileal and lymph node lesions contained high-grade malignant features compatible with plasmablastic lymphoma. Because his abdominal lymph nodes recurred 6 months after resection, he received six cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), and had a complete remission. Although his case was complicated by acute promyelocytic leukemia, he has so far survived, recurrence-free, for more than 7.5 years after chemotherapy for extraosseous plasmacytoma.

Keywords: CD20; Epstein-Barr virus (EBV); R-CHOP; ileal extraosseous plasmacytoma; lymph node involvement; plasmablastic lymphoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Gross findings of the primary lesion. A 6.5 cm × 4.0 cm tumor (A) was observed in the terminal ileum (arrows). The tumor was elevating and had a subpedunculated feature (B).
Figure 2
Figure 2
Histopathological findings. In the primary lesion (A), the tumor showed consistent with plasmacytoma. In some areas of the primary lesion (B), plasmablastic lymphoma-like features were observed. In the regional lymph nodes (C), involvement by plasmacytoma cells was observed (D). EBER in situ hybridization showed the tumor cells were positive. MIB-1 (Ki-67) labeling index of the tumor cells (E) was approximately 80%–90%. Primary lesion (F) was negative. Lymph node lesion (G) was positive. Notes: Original magnification of (A–G): ×400. (A–C) resulted from HE staining, (F and G) from CD20 immunostaining. Abbreviations: EBER, Epstein-Barr virus-encoded small nuclear RNA; HE, hematoxylin and eosin.
Figure 3
Figure 3
Abdominal computed-tomography findings. (A) The abdominal lymph nodes (indicated by arrow) were observed. (B) The lymph nodes disappeared after R-CHOP chemotherapy. Abbreviation: R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone.
See this image and copyright information in PMC

References

    1. Alexiou C, Kau RJ, Dietzfelbinger H, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer. 1999;85:2305–2014. - PubMed
    1. McKenna RW, Kyle RA, Kuehl WM, Grogan TM, Harris NL, Coupland RW. Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC; 2008. pp. 200–213.
    1. Lin BT, Weiss LM. Primary plasmacytoma of lymph nodes. Hum Pathol. 1997;28:1083–1090. - PubMed
    1. Susnerwala SS, Shanks JH, Banerjee SS, Scarffe JH, Farrington WT, Slevin NJ. Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. Br J Cancer. 1997;75:921–927. - PMC - PubMed
    1. Bachar G, Goldstein D, Brown D, et al. Solitary extramedullary plasmacytoma of the head and neck – long-term outcome analysis of 68 cases. Head Neck. 2008;30:1012–1019. - PubMed

Publication types