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. 2012 Jan;3(1):3-8.
doi: 10.3892/etm.2011.352. Epub 2011 Sep 20.

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Kiyoshi Kikuchi  1 , Nobuyuki Takeshige, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Chiemi Kikuchi, Narumi Iida, Hisaaki Uchikado, Naohisa Miyagi, Naoto Shiomi, Terukazu Kuramoto, Ikuro Maruyama, Motohiro Morioka, Ko-Ichi Kawahara
Affiliations

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Kiyoshi Kikuchi et al. Exp Ther Med. 2012 Jan.

Abstract

Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease-affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.

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References

    1. Lapchak PA, Zivin JA. The lipophilic multifunctional antioxidant edaravone (Radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Exp Neurol. 2009;215:95–100. - PubMed
    1. Wang CX, Shuaib A. Neuroprotective effects of free radical scavengers in stroke. Drugs Aging. 2007;24:537–546. - PubMed
    1. Green AR, Shuaib A. Therapeutic strategies for the treatment of stroke. Drug Discov Today. 2006;11:681–693. - PubMed
    1. Van der Worp HB, Kappelle LJ, Algra A, Bar PR, Orgogozo JM, Ringelstein EB, Bath PM, van Gijn J. The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology. 2002;58:133–135. - PubMed
    1. Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW, Emeribe U. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med. 2007;357:562–571. - PubMed