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. 2012 May;3(5):853-856.
doi: 10.3892/etm.2012.491. Epub 2012 Feb 17.

Polyethylene glycol 4000 treatment for children with constipation: A randomized comparative multicenter study

Yishi Wang  1 , Baoxi Wang, Xun Jiang, Mizu Jiang, Chundi Xu, Caihong Shao, Liying Jia, Zhihua Huang, Xiaohua Xu, Hua Liu, Lei Shang
Affiliations

Polyethylene glycol 4000 treatment for children with constipation: A randomized comparative multicenter study

Yishi Wang et al. Exp Ther Med. 2012 May.

Abstract

The aim of this study was to evaluate the efficacy and safety of polyethylene glycol 4000 (PEG 4000) for the treatment of constipation in children over 8 years of age. A total of 216 children from 7 hospitals were enrolled. A total of 105 patients received oral PEG 4000 (20 g/day) and 111 patients received oral lactulose (15 ml/day) for 2 weeks. The stool frequency, stool consistency and abdominal pain of the patients were monitored. In the PEG group, following one week and two weeks of treatment, the median weekly stool frequency improved from 2 times prior to treatment to 6 and 7 times, respectively, following treatment. The clinical remission rates of the PEG and lactulose groups following one week of treatment were 70.48 and 39.64%, respectively, and following two weeks of treatment were 72.38 and 41.44%, respectively. Abdominal pain disappeared in 74.6% of patients following two weeks of PEG 4000 treatment. No significant clinical adverse effects or abnormalities in the laboratory tests were observed in the two treatment groups. In conclusion, PEG 4000 is a safe and more effective drug compared to lactulose for the treatment of constipation in children.

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Figures

Figure 1.
Figure 1.
Effect of PEG 4000 and lactulose on stool frequency.
Figure 2.
Figure 2.
Effect of PEG 4000 and lactulose on stool consistency.
Figure 3.
Figure 3.
Clinical remission rates of children with constipation following PEG 4000 and lactulose treatment.
Figure 4.
Figure 4.
Remission rates of abdominal pain in children treated with PEG 4000 and lactulose.
See this image and copyright information in PMC

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