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Review
. 2012 Nov-Dec;34(6):545-53.
doi: 10.1016/j.ntt.2012.08.006. Epub 2012 Sep 3.

Zebrafish as potential model for developmental neurotoxicity testing: a mini review

Celine de Esch  1 , Roderick Slieker, André Wolterbeek, Ruud Woutersen, Didima de Groot
Affiliations
Review

Zebrafish as potential model for developmental neurotoxicity testing: a mini review

Celine de Esch et al. Neurotoxicol Teratol. 2012 Nov-Dec.

Abstract

The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.

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