Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Sep 13;489(7415):242-9.
doi: 10.1038/nature11552.

Functional interactions between the gut microbiota and host metabolism

Valentina Tremaroli  1 , Fredrik Bäckhed
Affiliations
Review

Functional interactions between the gut microbiota and host metabolism

Valentina Tremaroli et al. Nature. .

Abstract

The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.

PubMed Disclaimer

References

    1. Science. 2010 Apr 9;328(5975):228-31 - PubMed
    1. Nature. 2006 Dec 21;444(7122):1027-31 - PubMed
    1. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4523-30 - PubMed
    1. J Immunol. 2009 Dec 1;183(11):7514-22 - PubMed
    1. Obesity (Silver Spring). 2011 Nov;19(11):2280-2 - PubMed

Publication types

LinkOut - more resources