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. 2012 Dec;55(12):1673-6.
doi: 10.1093/cid/cis799. Epub 2012 Sep 12.

Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial

Jukka Jokinen  1 , Arto A Palmu, Terhi Kilpi
Affiliations

Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial

Jukka Jokinen et al. Clin Infect Dis. 2012 Dec.

Abstract

We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.

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