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. 2011 Nov;16(11):1397-404.

Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output

Mohammad Reza Khalilian  1 , Mohammad Reza Sabri, Abdolrasoul Nikyar, Shaghayegh Haghjooy Javanmard
Affiliations

Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output

Mohammad Reza Khalilian et al. J Res Med Sci. 2011 Nov.

Abstract

Background: Cardiac dysfunction is seen in many patients and could be evaluated with echocardiography and serum biomarkers. The aim of this study was evaluation of the relationship between echocardiographic findings and laboratory serum biomarkers in children with and without low cardiac output.

Methods: Thirty patients older than 1 month with and without low cardiac output were enrolled in this study. It composed of 13 patients with dilated cardiomyopathy (DCM), 7 with end stage renal disease (ESRD) and 10 who had a Fontan operation. Echocardiography was performed with emphasis on shortening fraction (SF) and ejection fraction (EF). Blood samples were collected for measurement of atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP) and alkaline phosphatase (Alk-P). Both echocardiographic findings and laboratory data were compared with control levels in twenty-seven normal children. Pearson correlation and regression analysis were conducted to evaluate the aforementioned associations.

Results: The mean of ANP and hs-CRP in the case group was statistically higher than control group (p < 0.001). The mean of ANP and hs-CRP were different in all groups (p < 0.001). There was a reverse linear regression between the SF and ANP in the case group (r = -0.594, p < 0.001).

Conclusions: Determination of the plasma ANP and hs-CRP level may be helpful for decisions related to early diagnosis of patient with low cardiac output.

Keywords: Atrial Natriuretic Peptide; Ejection Fraction; High Sensitivity C-reactive Protein; Shortening Fraction.

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Conflict of interest statement

Conflict of Interests Authors have no conflict of interests.

Figures

Figure 1
Figure 1
Correlation of shortening fraction to serum concentration of atrial natriuretic peptide in case group
Figure 2
Figure 2
Correlation of ejection fraction to serum concentration of atrial natriuretic peptide in case group
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References

    1. Kliegman RM, Stanton BMD, Geme JS, Schor N, Behrman RE. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders; 2007. pp. 1976–8.
    1. Anderson RH, Baker EJ, Penny D N, Rigby ML, Wernovsky G. Pediatric Cardiology. 3rd ed. Edinburg: Churchill Livingston; 2010. pp. 94–5.
    1. Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci. 1982;389:39–48. - PubMed
    1. Roberts WL, Moulton L, Law TC, Farrow G, Cooper-Anderson M, Savory J, et al. Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2. Clin Chem. 2001;47(3):418–25. - PubMed
    1. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD) J Am Coll Cardiol. 1996;27(5):1201–6. - PubMed

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