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. 2011 Sep;16(9):1129-38.

A randomized comparative trial of combinational methods for preventing post-spinal hypotension at elective cesarean delivery

Mitra Jabalameli  1 , Hassan Ali Soltani, Jalal Hashemi, Shekoofe Behdad, Bahram Soleimani
Affiliations

A randomized comparative trial of combinational methods for preventing post-spinal hypotension at elective cesarean delivery

Mitra Jabalameli et al. J Res Med Sci. 2011 Sep.

Abstract

Background: Various methods have been applied to prevent maternal hypotension after spinal anesthesia for cesarean delivery. We compared the efficacy of three combinational methods in this regard in the current study.

Methods: In this randomized comparative trial, 150 candidates of elective cesarean delivery under spinal anesthesia were assigned to three groups: crystalloid preload and leg bandage, colloid preload and leg bandage, and ephedrine and leg bandage. Maternal hemodynamic changes during 60 minutes after spinal injection and neonatal condition were compared among the groups.

Results: The cumulative incidence of hypotension was 54%, 64%, and 36% in groups 1 to 3, respectively (p = 0.018). Spinal injection to hypotension interval was similar among the groups (p = 0.828). Heart rate in group 3 was significantly lower at the most time measures after anesthesia compared with the other two groups (p < 0.05 to <0.001). Regarding neonatal outcomes, the interval between the birth and the first breath was longer and the Apgar score at minute 1 was lower in group 3 compared with the other groups (p < 0.001 and 0.038, respectively) but it was not clinically important. Umbilical cord blood pH was similar among the three groups (p = 0.248).

Conclusions: Among the three studied methods, administration of ephedrine plus bandage of the lower extremities was the most effective one in reducing the incidence of post-spinal hypotension. The groups were not clinically different concerning the effect of treatment on newborn health.

Keywords: Apgar Score; Cesarean Delivery; Hypotension; Prophylaxis; Spinal Anesthesia.

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Conflict of interest statement

Conflict of Interests Authors have no conflict of interests.

Figures

Figure 1
Figure 1
Flow diagram of enrolled study patients.
Figure 2
Figure 2
Systolic blood pressure changes during 60 minutes after spinal injection Group 1: Crystalloid+leg bandage Group 2: Colloid+leg bandage Group 3: Ephedrine+leg bandage p < 0.001
Figure 3
Figure 3
Kaplan-Meier survival curves showing the proportion of patients who remained not hypotensive until 60 minutes after anesthesia Group 1: Crystalloid+leg bandage Group 2: Colloid+leg bandage Group 3: Ephedrine+leg bandage p = 0.828
See this image and copyright information in PMC

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