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. 2012:2012:856381.
doi: 10.1155/2012/856381. Epub 2012 Aug 30.

Pleurotus tuber-regium Polysaccharides Attenuate Hyperglycemia and Oxidative Stress in Experimental Diabetic Rats

Hui-Yu Huang  1 , Mallikarjuna Korivi, Ying-Ying Chaing, Ting-Yi Chien, Ying-Chieh Tsai
Affiliations

Pleurotus tuber-regium Polysaccharides Attenuate Hyperglycemia and Oxidative Stress in Experimental Diabetic Rats

Hui-Yu Huang et al. Evid Based Complement Alternat Med. 2012.

Abstract

Pleurotus tuber-regium contains polysaccharides that are responsible for pharmacological actions, and medicinal effects of these polysaccharides have not yet been studied in diabetic rats. We examined the antidiabetic, antihyperlipidemic, and antioxidant properties of P. tuber-regium polysaccharides in experimental diabetic rats. Forty rats were equally assigned as diabetic high-fat (DHF) diet and polysaccharides treated DHF groups (DHF+1P, DHF+2P, and DHF+3P, 20 mg/kg bodyweight/8-week). Diabetes was induced by chronic low-dose streptozotocin injections and a high-fat diet to mimic type 2 diabetes. Polysaccharides (1P, 2P, and 3P) were extracted from three different strains of P. tuber-regium. Fasting blood glucose and glycosylated hemoglobin (HbA1c) levels substantially decreased, while serum insulin levels were restored by polysaccharides treatment compared to DHF. Furthermore, plasma total cholesterol, triglycerides, and low-density lipoprotein levels were significantly (P < 0.01) lower in polysaccharide groups. High-density lipoprotein levels were attenuated with polysaccharides against diabetes condition. Polysaccharides inhibited (P < 0.01) the lipid peroxidation index (malondialdehyde), and restored superoxide dismutase and glutathione peroxidase activities in the liver of diabetic rats. The antihyperglycemic property of polysaccharides perhaps boosts the antioxidant system that attenuates oxidative stress. We emphasize that P. tuber-regium polysaccharides can be considered as an alternative medicine to treat hyperglycemia and oxidative stress in diabetic rats.

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Figures

Figure 1
Figure 1
Fasting blood glucose levels (a) and oral glucose tolerance test (b) after 6-week polysaccharides (1P, 2P, and 3P) treatment in STZ-injected diabetic rats with high-fat diet rats (DHF). The ∗ indicates a significant difference compared to DHF group (P < 0.01).
Figure 2
Figure 2
Polysaccharides (1P, 2P, and 3P) impact against lipid peroxidation (malondialdehyde (MDA) levels) in the liver of diabetic rats fed a high-fat diet (DHF). The ∗ indicates a significant difference compared to DHF group (P < 0.01).
Figure 3
Figure 3
Superoxide dismutase (SOD) activity in the liver of diabetic rats fed a high-fat diet (DHF) and treated with three different polysaccharides (1P, 2P, and 3P). The ∗ indicates a significant difference compared to DHF group (P < 0.01).
Figure 4
Figure 4
Glutathione peroxidase (GPx) activity in the liver of diabetic rats fed a high-fat diet (DHF) and treated with three different polysaccharides (1P, 2P, and 3P). The ∗ indicates a significant difference compared to DHF group (P < 0.01), † indicates a significant difference compared to DHF+1P (P < 0.05), and # indicates a significant difference compared to DHF+2P (P < 0.05).
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