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. 2012:2012:301274.
doi: 10.1155/2012/301274. Epub 2012 Sep 2.

Neonatal lupus erythematosus

Kam Lun Hon  1 , Alexander K C Leung
Affiliations

Neonatal lupus erythematosus

Kam Lun Hon et al. Autoimmune Dis. 2012.

Abstract

Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro/SSA and/or anti-La/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17-25%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential.

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References

    1. Garcia S, Campos-de-Carvalho AC. Neonatal lupus syndrome: the heart as a target of the immune system. Anais da Academia Brasileira de Ciencias. 2000;72(1):83–89. - PubMed
    1. Hornberger LK, Al Rajaa N. Spectrum of cardiac involvement in neonatal lupus. Scandinavian Journal of Immunology. 2010;72(3):189–197. - PubMed
    1. Perez MF, de Torres ME, Buján MM, Lanoël A, Cervini AB, Pierini AM. Neonatal lupus erythematosus: a report of four cases. Anais Brasileiros de Dermatologia. 2011;86(2):347–351. - PubMed
    1. McCuistion CH, Schoch EP., Jr. Possible discoid lupus erythematosus in newborn infant: report of a case with subsequent development of acute systemic lupus erythematosus in mother. AMA Archives of Dermatology and Syphilology. 1954;70(6):782–785. - PubMed
    1. Buyon JP, Clancy RM. Neonatal lupus syndromes. Current Opinion in Rheumatology. 2003;15(5):535–541. - PubMed