Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012:46:499-513.
doi: 10.1146/annurev-genet-110711-155550. Epub 2012 Sep 4.

Neural regeneration in Caenorhabditis elegans

Rachid El Bejjani  1 , Marc Hammarlund
Affiliations
Review

Neural regeneration in Caenorhabditis elegans

Rachid El Bejjani et al. Annu Rev Genet. 2012.

Abstract

Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) A regenerating Caenorhabditis elegans GABA (γ-aminobutyric acid) neuron after laser surgery, and (b) a neuron that has failed to respond to injury (21).
Figure 2
Figure 2
Diagram of mitogen-activated protein kinase signaling during regeneration in Caenorhabditis elegans. Adapted from , .
See this image and copyright information in PMC

References

    1. Aguayo AJ, Bray GM, Rasminsky M, Zwimpfer T, Carter D, Vidal-Sanz M. Synaptic connections made by axons regenerating in the central nervous system of adult mammals. J. Exp. Biol. 1990;153:199–224. - PubMed
    1. Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity. Exp. Neurol. 2011;235:43–52. - PMC - PubMed
    1. Allen PB, Chiu DT. Calcium-assisted glass-to-glass bonding for fabrication of glass microfluidic devices. Anal. Chem. 2008;80:7153–7157. - PMC - PubMed
    1. Appenzeller O, Palmer G. The cyclic AMP (adenosine 3′,5′-phosphate) content of sciatic nerve: changes after nerve crush. Brain Res. 1972;42:521–524. - PubMed
    1. Barritt AW, Davies M, Marchand F, Hartley R, Grist J, et al. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J. Neurosci. 2006;26:10856–10867. - PMC - PubMed

MeSH terms

LinkOut - more resources