doi: 10.1016/0167-4889(90)90181-c.
Effect of forskolin on synthesis of xyloside-initiated glycosaminoglycans in embryonic chick chondrocytes
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- PMID: 2297536
- DOI: 10.1016/0167-4889(90)90181-c
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Effect of forskolin on synthesis of xyloside-initiated glycosaminoglycans in embryonic chick chondrocytes
Biochim Biophys Acta.
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Abstract
The synthesis of sulfated glycosaminoglycan (GAG) chains has been studied in the presence of various concentrations of the artificial acceptor 4-methylumbelliferyl beta-D-xyloside and of forskolin. Sulfated GAG chains formed in the presence of forskolin had a smaller hydrodynamic radius than controls, as revealed by chromatography on Sepharose CL-6B. Sulfated GAGs from both control and treated cultures behaved identically when chromatographed on DEAE.
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