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Review
. 2012;5(7):710-4.
Epub 2012 Sep 5.

Cerebral metastasis of cervical cancer, report of two cases and review of the literature

Reza Setoodeh  1 , Ardeshir Hakam, Yuan Shan
Affiliations
Review

Cerebral metastasis of cervical cancer, report of two cases and review of the literature

Reza Setoodeh et al. Int J Clin Exp Pathol. 2012.

Abstract

Cervical cancers spread locally through the angiolymphatic apparatus and very rarely metastasize to the brain. The intracranial metastasis is a late event and a sign of poor prognosis. We present two cases of uterine cervical carcinomas with brain metastasis presenting with severe headaches in one case and hemiparesis and aphasia in the other one. Palliative craniotomy and debulking of the tumor was performed in both patients.

Keywords: Cervical cancer; brain metastases; carcinoma of uterine cervix; intracranial metastasis; metastatic cervical cancer.

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Figures

Figure 1
Figure 1
Case 1, MRI of the brain. A 4.0 cm space occupying lesion in the parieto-occipital region (arrow) is the largest intracranial metastasis.
Figure 2
Figure 2
Case 1, Pathology. Poorly differentiated carcinoma with features of glandular and squamous differentiation, infiltrating the brain parenchyma. A: H&E (low power). B: H&E (higher power). C: p53 immunostain. D: p-CEA stain.
Figure 3
Figure 3
Case 2, Pathology. Brain tissue involvement by poorly differentiated squamous cell carcinoma. A: H&E (low power). B: H&E (higher power). C: p16 immunostain. D: Synaptophysin stain revealing neuroendocrine differentiation.
See this image and copyright information in PMC

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