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. 2012 Aug;153(4):559-62.
doi: 10.1007/s10517-012-1766-9.

Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins

[Article in English, Russian]
V Kh Khavinson  1 , N S Lin'kova, V O Polyakova, I M Kvetnoy, V V Benberin, M M D'yakonov, Yu S Titkov
Affiliations

Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins

[Article in English, Russian]
V Kh Khavinson et al. Bull Exp Biol Med. 2012 Aug.

Abstract

Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.

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