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Comparative Study
. 2012 Dec;41(6):388-93.
doi: 10.1111/jmp.12002. Epub 2012 Sep 17.

Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans

J F Brinkworth  1 , E A Pechenkina, J Silver, S M Goyert
Affiliations
Comparative Study

Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans

J F Brinkworth et al. J Med Primatol. 2012 Dec.

Abstract

Background: African catarrhine primates differ in bacterial disease susceptibility.

Methods: Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR.

Results: Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent.

Conclusions: These primates tend to generate species rather than agonist-specific responses to bacterial agonists.

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Figures

FIGURE 1
FIGURE 1
African catarrrhine early cytokine and chemokine responses to stimulation with TLR2 and TLR4 PAMPs. Human (orange squares), chimpanzee (blue circles) and baboon (black diamonds) blood was stimulated with LPS from E. coli 0111:B4, LMMS and Pam3CSK4 for 90 minutes and chemokine/cytokine induction was quantified by real-time PCR. 10 ug dose shown as Log base 2 here. Colored bars represent standard error of the mean (SEM), while black bars represent the mean. Dots in the scatter represent different individuals. Pairwise comparisons of significant different in gene induction were completed by unpaired t-tests [<0.05, unless otherwise noted. P value pairwise by PAMP was non significant for CXCL2 – LPS: H-B, LMMS: H-C, Pam3CSK4: H-C; for IL-8/CXCL8 - Pam3CSK4: H-B; for CCL3 – LPS: H-C, LMMS: H-C, H-B, Pam3CSK4: H-C, C-B, H-B; for IL-1β - LPS: H-B, Pam3CSK4: C-B; for IL-6 – LPS: H-C, LMMS: H-C, Pam3CSK4: H-C, C-B, H-B; TNFα -LPS: H-B, LMMS: H-C, C-B, Pam3CSK4: C-B; for IL-1RN – LPS: H-C, Pam3CSK4: H-C; for IL-10 – LPS: C-B, LMMS: H-C, Pam3CSK4: H-C; where human (H), chimpanzee (C ) and baboon (B)]
See this image and copyright information in PMC

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