Anemia, red blood cell transfusion, and outcomes after severe traumatic brain injury
- PMID: 22979948
- PMCID: PMC3682251
- DOI: 10.1186/cc11489
Anemia, red blood cell transfusion, and outcomes after severe traumatic brain injury
Abstract
In the previous issue of Critical Care, Sekhon and colleagues report that mean 7-day hemoglobin concentration <90 g/l was associated with increased mortality among patients with severe traumatic brain injury (TBI). The adverse relationship between reduced hemoglobin concentrations and outcomes among those with TBI has been an inconsistent finding across available studies. However, as anemia is common among adults with severe TBI, and clinical equipoise may exist between specialists as to when to transfuse allogeneic red blood cells, randomized controlled trials of liberal versus restricted transfusion thresholds are indicated.
Comment on
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Association of hemoglobin concentration and mortality in critically ill patients with severe traumatic brain injury.Crit Care. 2012 Jul 20;16(4):R128. doi: 10.1186/cc11431. Crit Care. 2012. PMID: 22817913 Free PMC article.
References
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- Kramer AH, Le Roux P. Red blood cell transfusion and transfusion alternatives in traumatic brain injury. Curr Treat Options Neurol. 2012. in press . - PubMed
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- Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;16:409–417. doi: 10.1056/NEJM199902113400601. - DOI - PubMed
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