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. 2011 Dec 29;4(1):217-28.
doi: 10.5539/gjhs.v4n1p217.

Isolation, analysis and antimicrobial activity of the acidic fractions of Mastic, Kurdica, Mutica and Cabolica gums from genus Pistacia

Mohammad Sharif Sharifi  1 , Stuart Loyd Hazell
Affiliations

Isolation, analysis and antimicrobial activity of the acidic fractions of Mastic, Kurdica, Mutica and Cabolica gums from genus Pistacia

Mohammad Sharif Sharifi et al. Glob J Health Sci. .

Abstract

The chemical entities of Mastic, Kurdica, Mutica and Cabolica gums from genus Pistacia have been isolated and characterised by GC-Mass Spectrometry, High Performance Liquid Chromatography and Column Chromatography. These chemical entities were screened for anti-microbial activities against nine strains of Helicobacter pylori and some other Gram-negative and Gram-positive bacteria. The most bioactive components were structurally analysed. These components mimic steroid compounds, in particular, the known antibiotic Fusidic acid. Some of these chemical entities have produced promising data that could lead to the development of a novel class of antimicrobial agents that may have application in the treatment of infectious disease. Kill kinetics have been also performed, and the produced data were evaluated by Generalized Multiplicative Analysis Of Variance (GEMANOVA) for the bactericidal and bacteriostatic activities which can be clinically significant. The isolated components were all bactericidal.

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Figures

Figure 1
Figure 1
Tetraoxane derivative of steroid
Figure 2
Figure 2
Methyl moronate
Figure 3
Figure 3
Methyl oleanonate
Figure 4
Figure 4
Ursonic acid (Methyl ester)
Figure 5
Figure 5
Methyl oleanolate
Figure 6
Figure 6
(R=O), Figure 9 (R=β-OH, H) and Figure 11 (α-CH3COO)
Figure 7
Figure 7
(R=O), Figure 8 (R=α-OH, H) and Figure 10 (α-CH3COO)
See this image and copyright information in PMC

References

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MeSH terms

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