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Comment
. 2012 Sep 14;47(5):667-8.
doi: 10.1016/j.molcel.2012.08.019.

Janus-faced PIDD: a sensor for DNA damage-induced cell death or survival?

Francis McCoy  1 , Laura Eckard, Leta K Nutt
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Janus-faced PIDD: a sensor for DNA damage-induced cell death or survival?

Francis McCoy et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, an activator of the PIDDosome (a complex comprising of PIDD, RAIDD, and caspase-2) is described in experiments detailing endogenous PIDDosome assembly and caspase-2 function after DNA damage in the presence of Chk1 suppression (Ando et al., 2012).

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